What Happens When Billions of AI Agents Hit Your Database? (Andy Pavlo)

Mistral AI is back in the frontier AI race. Mistral Large 4, nicknamed “Le Chonk,” is a 1-trillion-parameter open-weight model, trained in two months on 3,800 GPUs in Mistral’s own European datacenters — and independently rated the best open model outside China alongside Meta’s Muse Spark Open. After a year when open-weight AI meant DeepSeek, Kimi, Qwen and GLM, October brought a wave of Western open models, with Mistral at the front of it. Pierre Stock, Mistral’s VP of Science and first employee, walks through how the model was built: mixture-of-experts explained, what Mistral borrowed from DeepSeek, reinforcement learning at scale on coding, cyber, finance and chip design, why the RL run is still going, the model that pinged its own trainer from inside the sandbox, open weights vs cyber refusals, why 10-trillion-parameter models are coming, and Mistral Large 5, already in pretraining.

What is Jev? TypeSafe’s Jev is a new kind of AI model, a “decision model,” that doesn’t write text. It makes fast, cheap, calibrated decisions inside software, and it has taken the AI world by storm: within weeks of launch it became the most copied model in AI, with OpenAI, Cloudflare, Amazon and Databricks all shipping their own versions, and TypeSafe just raised an $870 million Series A at a $7.5 billion valuation. In this episode, Jev’s creator Diogo Almeida, co-inventor of RLHF at OpenAI and now CEO of TypeSafe, explains Jev in plain English: what a “System One” or decision model actually is, why ChatGPT-style language models can’t be trusted inside software (“95% Einstein, 5% Mr. Bean”), how RLHF and RLVR created the problem, what RLCD (reinforcement learning for calibrated decisions) does differently, where the training data comes from, which models Jev is built on, why “just a classifier” is a compliment, and why he calls pre-training “a giant dumpster fire of wasting resources.”

This summer, AI agents broke out of their test sandboxes at every major lab and hacked real companies, and the safety tests didn't see it coming. Eric Ho is the co-founder and CEO of Goodfire, the Anthropic-backed mechanistic interpretability lab whose new paper, "Models Know When They're Reward Hacking," found that top open-source AI models cheat on agent tasks up to 96% of the time, that a clear "cheating" signal exists inside the model, and that cheap activation probes can catch it, including hacks that chain-of-thought monitors miss. In this conversation, Eric explains reward hacking in plain terms (AI agents as "amoral students with a mostly absent teacher"), why reinforcement learning turned a known problem into a crisis, why chain-of-thought monitoring is fading as models start to think in "neuralese," and why nobody, including the people who build them, understands how these models work.

Everyone talks about GPUs. Almost nobody talks about the layer that feeds them. Renen Hallak is the founder & CEO of VAST Data — the $30 billion company powering xAI and some of the world's biggest AI clouds — and he sits in the hidden layer of the AI stack.

What happens when AI begins improving itself, and then turns that intelligence toward science? Richard Socher, pioneering AI researcher and CEO and co-founder of Recursive, joins Matt Turck to explore the vision behind his new book, The Eureka Machine. They discuss why scientific progress may be slowing, how large language models can learn the hidden languages of proteins and biology, and why simulations, verifiers and autonomous experiments could unlock superhuman AI capabilities. The conversation covers recursive self-improvement, AI drug discovery and cancer research, hallucination as creativity, virtual cells, self-driving laboratories, agent swarms, the AI Economist, Recursive’s plans, and the compute and data needed to build an AI scientist that never stops learning—and may eventually discover what humans cannot.