Show Notes
Access the mentioned courses here: Sleep And Psychiatry:
https://psychscene.co/46d0T09 ADHD and Sleep Dysfunction: https://psychscene.co/4rrE9Cc In this episode, Dr Sanil Rege explores the "how and why" of sleep by analysing a 2025 Neuron perspective paper (https://pubmed.ncbi.nlm.nih.gov/40961940/) detailing the interplay between sleep, motor circuits, and catecholamine biology. The discussion unpacks the motor theory of sleep, in which sleep control is embedded within somatic and autonomic motor circuits, and the catecholamine hypothesis, which posits that a core biological function of sleep is the inactivation of dopamine, noradrenaline, and adrenaline. This podcast provides clinicians with a neuroscientific framework for understanding sleep as an active state transition involving a global downshift of somatic and autonomic motor systems. #Sleep #Neuropsychiatry #Insomnia
More from Thinking In Psychiatry
View the mentioned paper here: Memantine to Treat Social Impairment in Youths With Autism Spectrum Disorder https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2839518 Access the mentioned course here: Understanding Autism Spectrum Disorder: A Comprehensive Guide to Clinical Assessment & Diagnosis https://psychscene.co/4zXOHNW In this video, Dr Sanil Rege examines a 2025 randomised controlled trial of memantine for social impairment in young people with Autism Spectrum Disorder (ASD).
Access mentioned course here: Advanced Psychiatric Formulation and Strategic Management Masterclass https://psychscene.co/3Rn0Sm3 Here is the link to the paper mentioned: Towards a Consensus Roadmap for a New Diagnostic Framework for Mental Disorders https://www.sciencedirect.com/science/article/pii/S0924977X24007168 In this episode, Dr Sanil Rege examines a 2025 ECNP consensus roadmap calling for psychiatry to move beyond descriptive diagnosis towards biology-informed, transdiagnostic, and mechanism-based models. He explores how circuit biomarkers, inflammation, genomic overlap, digital phenotyping, and machine learning may refine patient stratification, treatment selection, and relapse prediction across traditional diagnostic boundaries. This video provides clinicians with a neurobiological framework for shifting from label-based treatment to mechanism-informed formulation in psychiatric practice.
Here are the links to the papers mentioned: Parkinson’s disease as a somato-cognitive action network disorder Ren et. al.
Access mentioned course here: https://psychscene.co/46iAaiI In this episode, Consultant Psychiatrist, Dr Sanil Rege examines the complex relationship between ADHD pharmacotherapy and the emergence of psychotic symptoms. By analysing synthesis data from The Lancet Psychiatry (https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(25)00248-2/abstract), the podcast distinguishes between drug-induced events and baseline neurobiological vulnerabilities inherent in ADHD populations.