Show Notes
Here are the links to the papers mentioned: Parkinson’s disease as a somato-cognitive action network disorder Ren et. al.
The brain’s action-mode network Dosenbach et. al.
https://psychscene.co/4ts1pRr Access mentioned courses here: Advanced Psychiatric Formulation and Strategic Management:
ADHD Masterclass:
In this video, Dr Sanil Rege examines the Action Mode Network as a unifying clinical framework for understanding how the brain regulates action, arousal, body state, and cognition.
He explores the counterbalance between action mode and default mode, showing how impaired initiation, hyperarousal, poor state shifting, and social withdrawal may be better understood as disturbances of mode regulation rather than isolated symptom categories.
This session provides clinicians with a neurobiological framework for refining psychiatric formulation through the lens of state regulation, brain–body integration, and network-based clinical reasoning.
Chapters: 01:32 – Introducing the Action Mode Network 03:17 – The Brain as an Organ Organised for Action 05:48 – Action Mode vs Default Mode 07:18 – Psychiatric Syndromes as Mode-Switching Disorders 09:48– Overcoming the False Dichotomy of Mind and Body 12:25 – The PACES Model in Clinical Formulation 14:48 – Translating State Regulation into Clinical Practice
#ActionModeNetwork #Psychiatry #Brain
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View the mentioned paper here: Memantine to Treat Social Impairment in Youths With Autism Spectrum Disorder https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2839518 Access the mentioned course here: Understanding Autism Spectrum Disorder: A Comprehensive Guide to Clinical Assessment & Diagnosis https://psychscene.co/4zXOHNW In this video, Dr Sanil Rege examines a 2025 randomised controlled trial of memantine for social impairment in young people with Autism Spectrum Disorder (ASD).
Access mentioned course here: Advanced Psychiatric Formulation and Strategic Management Masterclass https://psychscene.co/3Rn0Sm3 Here is the link to the paper mentioned: Towards a Consensus Roadmap for a New Diagnostic Framework for Mental Disorders https://www.sciencedirect.com/science/article/pii/S0924977X24007168 In this episode, Dr Sanil Rege examines a 2025 ECNP consensus roadmap calling for psychiatry to move beyond descriptive diagnosis towards biology-informed, transdiagnostic, and mechanism-based models. He explores how circuit biomarkers, inflammation, genomic overlap, digital phenotyping, and machine learning may refine patient stratification, treatment selection, and relapse prediction across traditional diagnostic boundaries. This video provides clinicians with a neurobiological framework for shifting from label-based treatment to mechanism-informed formulation in psychiatric practice.
Access the mentioned courses here: Sleep And Psychiatry:
Access mentioned course here: https://psychscene.co/46iAaiI In this episode, Consultant Psychiatrist, Dr Sanil Rege examines the complex relationship between ADHD pharmacotherapy and the emergence of psychotic symptoms. By analysing synthesis data from The Lancet Psychiatry (https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(25)00248-2/abstract), the podcast distinguishes between drug-induced events and baseline neurobiological vulnerabilities inherent in ADHD populations.