Show Notes
Welcome back to the trenches! In our final breakdown of the 2026 ACC/AHA lipid guidelines, we are unpacking the pharmacology toolbox. From statins and ezetimibe to PCSK9 inhibitors and the nuances of side effects like SAMS, I want to give you the practical, evidence-informed strategies we need for our patients. We are all just trying to navigate this together.
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CHAPTERS: 00:00 - Intro 00:01:00 - Statin Mechanism of Action 00:01:34 - Types of Statins and Intensities 00:03:04 - Hydrophobic vs Hydrophilic Statins 00:05:15 - Statins and Glycemic Control 00:06:14 - Pleiotropic Effects of Statins 00:07:12 - Statin Side Effects Overview 00:08:36 - Ezetimibe as First-Line Add-On 00:09:54 - Bempedoic Acid 00:11:18 - PCSK9 Inhibitors 00:13:16 - Inclisiran and siRNA Therapy 00:14:26 - Bile Acid Sequestrants 00:15:47 - The Rule of 6 and Combination Therapy 00:17:16 - Statin-Associated Muscle Symptoms 00:19:04 - CoQ10 Supplementation 00:20:07 - Special Populations: Older Adults and Pregnancy 00:21:20 - Liver Safety and Drug Interactions 00:23:15 - Statins, Dementia, and Brain Fog 00:24:23 - Statins and Diabetes Risk 00:25:21 - Managing High Triglycerides 00:27:06 - Conclusion and Summer Sabbatical
SELECTED REFERENCES:
https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423
*Disclaimer* This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.
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