Show Notes
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What if a single blood test could reveal a hidden, lifelong risk for heart disease that affects one in five people? This risk factor, Lipoprotein(a), is almost entirely determined by your genes and doesn't improve with diet or exercise. In this episode, I break down everything you need to know about Lp(a) and why asking your doctor for this simple, once-in-a-lifetime test could be a game-changer for your health.
CHAPTERS: 00:00 - Introduction 00:44 - What is Lp(a)? 01:30 - The Genetics of Lp(a) 02:27 - 4: Kringle Repeats 03:20 - 5: Epidemiology 04:06 - 6: Global Impact of Lp(a) 04:50 - 7: Why It Actually Causes Increased Risk 05:50 - 8: Atherogenic Pathway 06:31 - 9: Lp(a) and Plaque Stability 07:22 - 10: Pro Inflammatory Pathway 07:57 - 11: Local Inflammation Doesn’t Always Mean Systemic Inflammation 09:03 - 12: Pro Thrombotic Pathway 10:04 - 13: Clinlical Manifestations 10:48 - 14: Screening Recommendations 11:37 - 15: Measuring Lp(a) 13:20 - 16: Defining High Risk Lp(a) 14:32 - 17: Current Management Principles 15:11 - 18: Lowering LDL 17:08 - 19: Statins, Ezetimibe, and Bempedoic Acid 18:25 - 20: PCSK9i and Omega 3’s 19:31 - 21: Therapies to Avoid 20:39 - 22: RNA Based Treatments 21:17 - 23: Antisense Oligonucleotides- Pelacarsen 22:00 - 24: siRNAs- Olpasiran 22:50 - 25: Muvalaplin- An Oral RNA Option 23:28 - 26: Lp(a)/Diabetes Paradox 24:17 - 27: High Risk Populations 25:18 - 28: Key Unanswered Questions 25:53 - 29: Key Takeaways 26:36 - 30: The Future
SELECTED REFERENCES: https://doi.org/10.3390/ph18050753 https://doi.org/10.1016/j.jacl.2024.03.001 https://doi.org/10.37532/1755-5310.2023.15(S16).395 https://doi.org/10.1161/ATV.0000000000000147 https://doi.org/10.1016/j.ajpc.2024.100651
*Disclaimer* This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.
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