Evidence based conversation

Professor Angus Dalgleish, mRNA Vaccines Must Be Banned Once and For All

High infection rates in UK, going down in USUploaded 19-10-21https://www.telegraph.co.uk/news/2021/10/19/people-must-cautious-day-to-day-interactions-covid-cases-climb/Lower functional immunity in our population than most other Western European countriesEarly vaccine roll outAstraZeneca protects slightly less well than Pfizer against infection and transmission, particularly delta variantSlightly lower overall vaccination coverage, particularly vaccinating teenagersFewer social restrictionsHigh rates of testingUK, ONS https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/coronaviruscovid19/latestinsightsTwo vaccine doses give similar protection as previous infection Two doses of either Pfizer-BioNTech or Oxford-AstraZenecaProvided a similar level of protection as having had a previous natural infection of coronavirusDuring delta variant timesVaccination reduced the risk of testing positive, both when the alpha variant was dominant in the UK (1 December 2020 to 16 May 2021) and when the delta variant was dominant (17 May to 14 August 2021)Two doses of Pfizer-BioNTechReduced the risk of testing positive by 73% in the delta periodTwo doses of Oxford-AstraZenecaReduced the risk of testing positive by 62% in the delta periodTwo vaccination doses, more effective than one at preventing symptomatic infection in both periods. Three weeks after vaccinationTwo doses always more protective than one(75% v 58%)Inconsistent with covid symptom studyhttps://covid.joinzoe.com/post/do-i-need-a-covid-vaccine-if-ive-had-covidTwo doses of the Pfizer87% protection against infectionTwo doses of the AstraZeneca71% protection against infectionNatural infection aloneOnly gave 65% protection against catching it againIsraeli data consistent with ONS but inconsistent with covid symptom studyProtection of previous SARS-CoV-2 infection is similar to that of BNT162b2 vaccine protection: A three-month nationwide experience from Israel https://www.medrxiv.org/content/10.1101/2021.04.20.21255670v1.full.pdfVaccination was highly effective Estimated efficacy for documented infection of 92·8% Hospitalization 94·2% Severe illness 94·4% Death 93·7% Protection from prior SARS-CoV-2 infectionEstimated efficacy for documented infection of 94·8% Hospitalization 94·1% Severe illness 96·4%All deaths registered in the week to 8 October COVID-19 deaths fall in England, Northern Ireland and ScotlandUp in WalesTotal UK deaths in the week, 12,49014.7% above the average in 2015 to 2019820 involved the coronavirus (COVID-19)154 fewer than the previous weekDeaths involving COVID-19, 1 in 15 deaths (6.6%).UK total deaths include non-residents.1 million people in UK countries had COVID-19 in the latest week1.63% in England (1 in 60 people)One in 70 people the week before2.18% in Wales (1 in 45 people)One in 55 people the week before 0.82% in Northern Ireland (1 in 120 people)One in 130 people the week before 1.26% in Scotland (1 in 80 people)One in 60 people the week beforeGreg and PeterHello John, Just to let you know that one of my posts referring to your video on aspiration has been pulled from LinkedIn. This is the first time that one of my posts has been pulled and I have put out some pretty controversial posts on other subjects.Feedback from vaccine manufacturers Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices

WHO and YTUploaded 07-11-22https://www.who.int/teams/digital-health-and-innovation/digital-channels/combatting-misinformation-onlineWHO works with social media policy departments to ensure company policy and guidelines for content providers are fit for purpose.John’s e [email protected]://www.who.int/campaigns/connecting-the-world-to-combat-coronavirus/how-to-report-misinformation-onlineWHO provide a helpful guide on how to report misinformation onlineInaccurate information spreads widely and at speed, making it more difficult for the public to identify verified facts and advice from trusted sources, such as their local health authority or WHO.https://support.google.com/youtube/answer/9795167?hl=enAs a starting point in the UK, only NHS organisations are being invited to self-certify against the NHS Standard for Creating Health Content. By completing the self-certification process, an NHS organisation channel will be eligible for information panels indicating NHS credibility. From FDA to MHRA: are drug regulators for hire?https://www.bmj.com/content/377/bmj.o1538.fullRegulatory agencies, large proportions of their budgets,funded by the industry they are sworn to regulateUS Food and Drug Administration (FDA)1992, Prescription Drug User Fee Act, allowing industry to fund the US Food and Drug Administration (FDA) directly through “user fees” Net PDUFA fees collected$29m in 1993$884m in 2016 (65% of budget)FDA, 9 out of 10 of its past commissioners between 2006 and 2019 went on to secure roles linked with pharmaceutical companiesEuropean Medicines Agency (EMA)Industry fees funded 20% European Medicines Agency (EMA), in 1995By 2010, 75%Today, 89%Medicines and Healthcare Products Regulatory Agency (MHRA)86% of funding from Pharmaceutical IndustryAustraliahttps://www.tga.gov.auProportion of TGA budget derived from industry, 96%WHO fundinghttps://app.powerbi.com/view?r=eyJrIjoiNzNmNTRkMWEtNmZjMS00NzdjLWEyMDYtYWExYzA4NzVhZGQwIiwidCI6ImY2MTBjMGI3LWJkMjQtNGIzOS04MTBiLTNkYzI4MGFmYjU5MCIsImMiOjh9https://www.weforum.org/agenda/2020/04/who-funds-world-health-organization-un-coronavirus-pandemic-covid-trump/The second-largest funder is the Bill and Melinda Gates Foundation, which provides 9.8% of the WHO's fundsAppendixhttps://genius.com/George-orwell-nineteen-eighty-four-appendix-the-principles-of-newspeak-annotatedhttps://www.orwell.ru/library/novels/1984/english/en_appIt was expected that Newspeak would have finally superseded Oldspeak (or Standard English, as we should call it) by about the year 2050The purpose of Newspeak was not only to provide a medium of expression for the world-view and mental habits proper to the devotees of Ingsoc, but to make all other modes of thought impossible.The C vocabulary was supplementary to the others and consisted entirely of scientific and technical terms. These resembled the scientific terms in use today, and were constructed from the same roots, but the usual care was taken to define them rigidly and strip them of undesirable meanings.War is peace, freedom is slavery, ignorance is strengthNext Monday, 14th November, evidence based medicine confrencehttps://www.eventbrite.co.uk/e/has-big-pharma-hijacked-evidence-based-medicine-tickets-444525075467 Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices

Serious Adverse Events Uploaded 02-06-25https://www.fda.gov/media/186738/download?attachmentMNEXSPIKE groupSerious adverse events were reported by 2.7% of participants (n=156) Comparator vaccineSerious adverse events were reported by and 2.6% of participants (n=151)(median follow-up of 8.8 months).https://cardiovascular-research-and-innovation.reseaprojournals.com/archive_files/Myocarditis%20after%20SARS-CoV-2%20infection%20and%20COVID-19%20vaccination%20Epidemiology,%20outcomes,%20and%20new%20perspectives.pdf https://investors.modernatx.com/news/news-details/2025/Moderna-Receives-U-S--FDA-Approval-for-COVID-19-Vaccine-mNEXSPIKE/default.aspxhttps://www.fda.gov/vaccines-blood-biologics/mnexspikeTargeted approach against the JN.1 variantParticipants received either mRNA-1283 or mRNA-1273. mRNA-1283 showed a 9.3% higher relative vaccine efficacy (rVE) compared to mRNA-1273 in individuals aged 12 years and older, a 13.5% higher rVE in adults aged 65 and older.https://clinicaltrials.gov/study/NCT05815498https://ctv.veeva.com/study/a-study-of-mrna-1283222-injection-compared-with-mrna-1273222-injection-in-participants-12-years-ohttps://ctv.veeva.comCONTRAINDICATIONS Do not administer MNEXSPIKE to individuals with a known history of severe allergic reactionMyocarditis and Pericarditis, increased risks of myocarditis and pericarditis, risk has been highest in males 12 years through 24 years of age. Onset of symptoms typically in the first week following vaccination Although some individuals with myocarditis and/or pericarditis following administration of mRNA COVID-19 vaccines have required intensive care support, available data suggest that individuals typically have resolution of symptoms within a few days with conservative management.In hospitalized patients who had been diagnosed with COVID-19 vaccine-associated myocarditis,Most of these patients had received a two-dose primary series of an mRNA COVID-19 vaccine prior to their diagnosis. In this study, https://www.thelancet.com/journals/eclinm/article/PIIS2589-5370(24)00388-2/fulltextat a median follow-up of approximately 5 months post-vaccination, persistence of abnormal cardiac magnetic resonance imaging (CMR) findings that are a marker for myocardial injury was common. The clinical and prognostic significance of these CMR findings is not knownInformation is not yet available about potential long-term sequelae of myocarditis or pericarditis following administration of mRNA COVID-19 vaccines. 5.3 Syncope Syncope (fainting) may occur in association with administration of injectable vaccines. 5.4 Altered Immunocompetence Immunocompromised persons, including individuals receiving immunosuppressive therapy, may have a diminished immune response to MNEXSPIKE5.5 Limitations of Vaccine Effectiveness MNEXSPIKE may not protect all vaccine recipients. 6 ADVERSE REACTIONS Most commonly (≥10%) reported adverse reactions following administration of MNEXSPIKE: Learn more about your ad choices. Visit megaphone.fm/adchoices Learn more about your ad choices. Visit megaphone.fm/adchoices

United States to follow. 200,000 new omicron infections per day in the UK now.