Why You're Exhausted, Anxious & Hormonally Wrecked — And What Methylation Has To Do With It | Dr Jean-Marc Sobczyk
The Health ReviewShow Notes
Methylation. Leaky gut. MTHFR. Biological age. Functional testing. Peptides.
These words are everywhere in health and wellness right now — but what do they actually mean, who are they relevant for, and how should they be approached?
In this episode of The Health Review, I sit down with Dr Jean-Marc Sobczyk from HOOKE clinic in London— a physician dual-trained in both conventional and naturopathic medicine, with deep expertise in advanced functional testing, methylation and root-cause health.
He's at the cutting edge of methylation science and runs a dedicated platform on the MTHFR gene and its implications for health.
This is one of the most clinically rich conversations I've had on the podcast — and one that I think will genuinely change how you think about your own health.
We cover:
What methylation actually is — and why it underpins energy, detox, hormone balance, mood and longevity The B vitamins that support the methylation cycle and how to use them intelligently MTHFR, COMT and other gene variants — what they mean in practice and how common they are How poor methylation shows up clinically: anxiety, burnout, hormonal issues, fatigue, low resilience Methylation and women's health — PMS, fertility, pregnancy prep, perimenopause The gut-methylation connection: why liver function and gut health are inseparable from how well you methylate Leaky gut and reactive gut — how to identify it, calm it and repair it Probiotics: when they help and when they don't Biological age testing, peptides and longevity medicine — what's worth it and what's noise The foundational things to focus on before spending money on complex testing
This episode is for you if:
You've been told your bloods are normal but you still don't feel well. You struggle with fatigue, anxiety, hormonal imbalance, gut issues or brain fog — and you want to understand what might actually be driving it.
About Dr Jean-Marc Sobczyk:
Dr Jean-Marc Sobczyk is a physician dual-trained in conventional and naturopathic medicine. He practises at HOOKE, a longevity and preventative medicine clinic, where he uses advanced functional testing alongside natural and integrative therapies to address root-cause health. He has a specialist focus on methylation and the MTHFR gene.
This episode is for educational purposes only and does not constitute medical advice. Always consult your own clinician before making changes to your health.
Topics: methylation | MTHFR gene | COMT | functional medicine | leaky gut | gut health | probiotics | biological age | peptides | longevity medicine | B vitamins | hormone balance | oestrogen detox | dopamine | neurotransmitters | personalised medicine | preventative health | anxiety and nutrition | women's hormones | perimenopause nutrition | fatigue root cause | naturopathic medicine
Dr Jean-Marc Sobczyk: https://www.instagram.com/mthfr_expert/
HOOKE: https://www.hooke.london/
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