
Show Notes
Josh Wolfe is a co-founder of Lux Capital, where he funds the kinds of ventures that change everything: think gene-edited pig organs and technology that lets you “record” smells. His approach? Relentless curiosity. He reads dozens of newspapers daily to identify patterns, always staying a few steps ahead. In this episode of The Generalist, Josh shares how his firm backs companies that don’t just predict the future, but create it.
In our conversation, we explore: • The revolutionary development of genetically modified pig organs being transplanted into humans and what this means for the future of organ transplantation. • The recent achievement of "teleporting smell" across space and why computers that can replicate scents will open up entirely new industries. • Why Lux is investing in the search for real-life "X-Men" — genetic outliers in isolated populations whose DNA could lead to life-saving medical advancements. • How Josh evaluates macro trends to make smarter micro investment decisions and why ignoring the big picture is a mistake. • The three tech sectors that Josh believes will define the geopolitical balance in the decades ahead. • How Josh stays current on macroeconomic trends. • Much more — Thank you to the partners who make this possible Brex: The banking solution for startups. WorkOS: The modern identity platform for B2B SaaS. Generalist+: Essential intelligence for modern investors and technologists. — For a full transcript of the episode, please visit: https://thegeneralist.substack.com/p/shrinking-the-gap-between-sci-fi-and-sci-fact-josh-wolfe — Timestamps (00:00) Intro (04:38) A brief overview of Josh’s work at Lux Capital (05:57) The science fiction to science fact pipeline (09:11) Xenotransplantation (12:10) Proven transplantations with modified pig kidneys, and what’s next (15:38) Ethical questions around xenotransplantation (17:48) Lux Capital’s investment in eGenesis (19:34) The theory of persistent cellular memory (23:35) Why eGenesis began with kidneys (24:30) Digitizing smell (32:24) Commercializing digital olfaction technology (38:26) The potential applications for a “Shazam for smell” (43:16) Variant Bio’s work studying genetic outliers (52:00) Variant Bio's two primary clinical focuses (53:46) How Josh stays current on macroeconomic trends (59:44) Josh’s thoughts on the critical areas the U.S. should invest in (1:14:00) How to win the talent war (1:18:53) Final meditations — Follow Josh Wolfe X: https://x.com/wolfejosh LinkedIn: https://www.linkedin.com/in/josh-wolfe-7883/ — Follow Mario Gabriele Newsletter: https://thegeneralist.substack.com/ LinkedIn: https://www.linkedin.com/in/mariogabriele/ — Resources and episode mentions
—Books— • 20,000 Leagues Under the Sea: https://www.amazon.com/000-Leagues-Under-Wordsworth-Classics/dp/1853260312 • War of the Worlds: https://www.amazon.com/War-Worlds-H-G-Wells/dp/8175992824/ • In Search of Lost Time: https://www.amazon.com/Search-Lost-Time-Library-Classics/dp/0812969642 • Perfume: The Story of a Murderer: https://www.amazon.com/Perfume-Story-Murderer-Patrick-Suskind/dp/0375725849/ • Poor Charlie's Almanack: The Wit and Wisdom of Charles T. Munger: https://www.amazon.com/Poor-Charlies-Almanack-Charles-Expanded/dp/1578645018
—Other Resources— • eGenesis: https://egenesisbio.com/ • Xenotransplantation: https://egenesisbio.com/xenotransplant/ • Surgeons Transplant Engineered Pig Kidney Into Fourth Patient: https://www.nytimes.com/2025/02/07/health/fourth-pig-kidney-transplant.html • CRISPR: https://www.genome.gov/genetics-glossary/CRISPR • Can an Organ Transplant Change Someone’s Personality? https://www.psychologytoday.com/us/blog/the-leading-edge/202402/do-organ-transplants-cause-personality-change-in-recipients# ...Episode resources continued at: https://thegeneralist.substack.com/p/shrinking-the-gap-between-sci-fi-and-sci-fact-josh-wolfe — Production and marketing by penname.co. For inquiries about sponsoring the podcast, email [email protected].
More from The Generalist
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